As we age, our body produces less hyaluronic acid, leading to dry and wrinkled skin. Hyaluronic acid fillers can replace the lost natural substance, making the skin look younger and more supple.

People who are worried about sagging skin or want to enhance their facial features can consider getting fillers to achieve a more youthful and balanced appearance.

  1. Temporary Fillers: These last around 4-6 months or more and are safe. They can naturally break down over time
  2. Semi-Permanent Fillers: These last longer, about 2 years, and are moderately safe.
  3. Permanent Fillers: Examples include silicone or paraffin, which stay in the skin indefinitely and don’t break down naturally. However, they can have long-term side effects.

The choice of filler depends on the specific problem you want to address. It’s important to note that filler brands approved by the FDA in Thailand contain only pure Hyaluronic acid (HA).

In order to achieve natural-looking results and solve problems that meet the patient’s concerns as much as possible, it is important that patients have knowledge about the brands and models of fillers that have been approved by the FDA for their benefits and Maximum safety of the patient

Juvederm Filler

Juvederm is an American filler. Which is popular with doctors around the world for using to adjust facial shape. It is produced by Allergan, a leader in cosmetic medicine from the United States.

Certified by the US FDA and the Thai FDA and imported by Allergan Thailand using 2 technologies in production (Hylacross Technology and Vycross Technology).

* Hylacross Technology is a technology that has outstanding properties in Good water holding value After injection, you will noticeably feel fuller because you use the filler type Hyaluronic Acid (Hyaluronic Acid: HA) which has high flexibility. and can withstand moving well

* Vycross Technology is the latest technology. that was developed to enhance the original properties for better lifting and tightening Contains dense adhesion molecules and has a low rate of swelling or water holding Compared to other HAs, it helps to make the results after injection smooth, not lumpy, and looks natural. and lasts a long time

There are 7 models in the Juvederm line, but there are 2 models that are very popular and currently on the market:

1. Juvederm Voluma: The texture of this filler is hard and dense. Moderately full Importantly, it is designed for injections in the cheeks, cheeks, and chin. It can also be injected in the temples and lips for fullness. Including under the eyes to help with bone atrophy as well. The results can last for up to 18 months.

2. Juvederm Volift: is a model designed to have a filler texture that is smooth, fine, soft, flexible, not lumpy, giving results after injection that look natural. Suitable for injections in the cheeks, nasolabial folds, under the eyes, and lips. Results after injection can last up to 12 months.

This depends on the care behavior and lifestyle behavior of each patient.

Hyabell Filler
Hyabell is another popular German filler brand. It is highly safe and has been CE certified in Europe since 2014, and is now widely sold and used in more than 20 countries around the world. Which in Thailand has been imported and distributed legally by KNA Interpharma Company of Thailand.

How many models of Hyabell filler are there? Where are they injected?
Hyabell fillers that have been certified by the Thai FDA and are properly distributed currently have 4 models.

1. Hyabell Lips

  •  Contains a concentration of hyaluronic acid (Hyaluronic Acid: HA) of 12 mg/ml (milligrams/ml) mixed with anesthetic lidocaine (Lidocaine) 3%.
  • The softest gel texture of the 4 models is suitable for injections to moisturize and correct wrinkles.
  • Recommended injection area: under the shallow eyelid Moisturizes the lips Permanently correct wrinkles (fine lines) around the corners of the eyes, around the mouth, and in the areola.
  • Decomposition period: 6-9 months

2. Hyabell Basic

  • Contains a concentration of hyaluronic acid (Hyaluronic Acid: HA) of 16 mg/ml (milligrams/ml) mixed with the anesthetic lidocaine (Lidocaine) 3%.
  • Medium hard gel texture Suitable for filling Corrects moderately deep grooves
  • Suitable areas for injection: under the deep eyelids, cheek grooves, areola, and mouth shaping.
  • Decomposition period: 6-9 months

3. Hyabell Deep

  •  Concentration of hyaluronic acid (Hyaluronic Acid : HA) 20 mg/ml (milligrams/ml) mixed with anesthetic lidocaine 3%
  • Hard gel texture, suitable for filling in medium to deep grooves. Because it can be shaped well Suitable for use in injections to reshape the face and lift it.
  • Suitable areas for injection: temples, cheeks, chin, and face frame.
  • Decomposition period: 9-12 months

4. Hyabell Ultra

  • Concentration of hyaluronic acid (Hyaluronic Acid : HA) 24 mg/ml (milligrams/ml) mixed with anesthetic lidocaine (Lidocaine) 3%
  • The hardest gel texture of all 4 models is stable, flexible, well moldable, suitable for injections to adjust facial shape and lift.
  • Suitable areas for injection: Temples, face and cheeks tightened. Adjust the shape of the chin and face frame
  • Decomposition period: 12-14 months

Restylane Filler
Restylane is another brand of fillers in the Hyaluronic Acid (Hyaluronic Acid: HA) group from Sweden. that has been widely accepted and popular in the medical community around the world And has passed FDA certification from the United States. Restylane is also the longest-established filler in the world and continues to be popular until now.

Restylane is owned by Galderma, a large pharmaceutical company in Sweden. Currently, Restylane filler production technology continues to develop continuously. There are two technologies that are exclusive to Restylane fillers: NASHA technology and OBT technology.

  • NASHA Technology or Non-Animal Stabilized Hyaluronic Acid Technology is a substance that has properties similar to Hyaluronic Acid (Hyaluronic Acid: HA) in the body, which is highly stable, safe, and able to prevent allergic reactions. It has been widely used since 1996. And currently it is used in more than 70 countries around the world. Receives FDA safety standards from the United States and CE Marks from Europe. The gel texture is small, medium, large, not the same in each model of filler. NASHA Technology is a technology that creates a gel that maintains its shape (Firm Gel). BDDE has been added to less than 1% to make Hyaluronic Acid (Hyaluronic Acid) or HA as close to nature as possible. To get a beautiful face shape Sharp and looks more dimensional In addition, after injection, there is no flow of filler to various areas, helping to add moisture to the skin and also being able to maintain the condition of the filler in our body for approximately 6 – 12 months after. Inject at once
  • OBT Technology or Optimal Balance Technology is another Restylane filler production technology that was produced after NASHA production that has a mesh structure, which is Restylane’s unique technology, resulting in a soft and smooth filler texture. resilient Sticks to the skin well. Get beautiful, smooth, natural looking results or suitable for people with sensitive skin. Therefore, it is widely accepted and used in the medical field all over the world. It is outstanding in terms of flexibility. The gel is stable, flexible, and can be adjusted to a variety of shapes to cover many problems in filling.

Restylan filler is a popular model used for filling. There are 3 models.

  1. Restylane Perlane Lyft : is a filler that contains anesthetic or lidocaine, which is commonly used for under-eye injections, nose injections, chin injections, or orange cheek fillers, depending on the needs of the person and Doctor’s evaluation Because it is highly stable, not fluffy, and can maintain its shape as best as possible. It can dissolve on
  2. Restylane Vital Light: This filler contains the anesthetic lidocaine. It is another popular model under the name Restylane. It is a light molecule filler with small particles and a smooth, fine texture. Can fix small problem spots, suitable for helping restore moisture to the skin. Revitalize the face to be radiant. Injected to capture details in areas where wrinkles occur, such as under the eyes, superficial skin, and mouth, with a decay time of approximately 6-12 months.
  3. Restylane Kysse: This filler model contains the anesthetic lidocaine (Lidocaine) like other fillers. It is one of the most popular fillers on the market for injections in the mouth area. The filler texture will be smooth and fine. But it is stable. Create clear lip edges Moisturize plumpness It is designed specifically for use in filling the lips. Along with helping to adjust the color of the lips to look brighter. Immediately after injection and results can be maintained for up to 12 months.

The model of filler used will be the type and quantity that will be evaluated by the patient’s doctor. Choose a model that has experience and can answer the patient’s problems. By choosing a filler type with molecular size To suit the position and skin condition of each patient.

E.p.t.q Filler
e.p.t.q is a filler that is very popular today. And it is becoming more and more popular because it is a safe and cheap filler compared to other filler brands on the market, which e.p.t.q is a famous filler brand from South Korea. It has started selling filler products since 2017 and has sold over a million boxes worldwide.

e.p.t.q. stands for
E : Efficiency
P : Potential
T : Technology modern technology
and Q: Quality Efficiency, which means Excellent quality

The e.p.t.q filler is highly effective because it contains a high concentration of Hyaluronic Acid (HA) at 24 mg/ml, which is considered quite high compared to other fillers on the market. It has minimal toxic residue and is made using advanced production technology, ensuring good quality. The molecules are small, fine, and flexible, adhering well to the skin.

The production process follows international standards, resulting in a filler with excellent texture (viscoelasticity) that maintains both viscosity and flexibility. This filler can produce very natural-looking results.

The e.p.t.q. filler is popular in the market due to its safety and affordable price. It is produced following strict standards under EP (European Pharmacopoeia) certification, ensuring it contains safe and pure Hyaluronic Acid (HA). The filler is thoroughly sterilized, leaving no chemical residue, and has a pH value similar to human skin. These qualities make e.p.t.q. a popular choice among users.

Additionally, the BDDE value is crucial to consider. BDDE (1,4-Butanediol diglycidyl ether) is a substance that helps the filler bond, a process known as cross-linking. The more bonds there are, the better the filler’s shape, making it dissolve slowly. This tight bonding pattern affects the filler’s fluffiness, viscosity, and flexibility, alloThe e.p.t.q. filler is popular in the market due to its safety and affordable price. It is produced following strict standards under EP (European Pharmacopoeia) certification, ensuring it contains safe and pure Hyaluronic Acid (HA). The filler is thoroughly sterilized, leaving no chemical residue, and has a pH value similar to human skin. These qualities make e.p.t.q. a popular choice among users.

Additionally, the BDDE value is crucial to consider. BDDE (1,4-Butanediol diglycidyl ether) is a substance that helps the filler bond, a process known as cross-linking. The more bonds there are, the better the filler’s shape, making it dissolve slowly. This tight bonding pattern affects the filler’s fluffiness, viscosity, and flexibility, allowing the results to be maintained for a longer time.wing the results to be maintained for a longer time.

The BDDE value, or 1,4-Butanediol diglycidyl ether, is a substance in fillers that helps them bond. This process, known as cross-linking, creates more bonds, improving the filler’s shape.

In fillers, it’s important to focus on maintaining their shape. More bonds in the filler lead to better results, and this is achieved by adding BDDE. However, excessive BDDE can cause problems, like allergic reactions. When there’s too much BDDE that cannot bind with Hyaluronic Acid (HA), it remains in the filler. This leftover BDDE can trigger various allergic reactions.

The e.p.t.q filler offers 3 product types: e.p.t.q. S 100, e.p.t.q. S 300, and e.p.t.q. S 500, providing options for different needs.

  1. e.p.t.q. S 100
    e.p.t.q. S 100: This is the softest version, used for superficial skin injections. It comes in a 1 ml syringe and helps smooth the skin, reduce wrinkles, and enhance natural skin texture. It’s suitable for areas under the eyes, temples, and mouth. The results last about 6 months, depending on the patient’s lifestyle.
  2. e.p.t.q. S 300
    e.p.t.q. S 300: S 300 has a firmer texture than S 100. It’s injected in middle and deep skin areas and maintains its shape well. This model is suitable for shaping different facial parts such as the forehead, sunken eyes, cheek grooves, and lips. The effects last around 8 months or possibly less, depending on the patient’s lifestyle.
  3. e.p.t.q. S 500
    e.p.t.q. S 500: S 500 is the densest and hardest model, providing strong lifting force. It’s used for deep skin injections and can replace missing bones caused by aging, addressing sagging facial skin. It’s commonly injected in the jaw, face frame, chin, nose, under the eyes, and cheeks. The results last approximately 12 months or less, based on the patient’s lifestyle and evaluation by the doctor.

Each of these models is available in two versions: a normal version without lidocaine and another version containing 0.3% lidocaine, an anesthetic for reduced discomfort during the procedure.

Neuramis Filler
Neuramis Filler is a popular brand from South Korea, gaining worldwide recognition similar to the e.p.t.q. brand. It’s known for its quality and affordability, making it widely used for facial injections. Many people choose Neuramis fillers to add volume to their face, achieve proportion, and reduce wrinkles.

Neuramis fillers offer a natural and smooth appearance, making them a popular choice for those wanting to enhance their facial features. The brand is certified by regulatory authorities like the Thailand Food and Drug Administration (THFDA), the United States (USDFA), and the European Committee for Quality of Medicines and Healthcare (EDQM). Neuramis fillers are imported by Medyceles Thailand.

Currently, there are 3 models of Neuramis fillers, all certified by regulatory standards including KFDA from Korea, U.S.FDA from the United States, EDQM from Europe, and Thailand’s FDA (updated in 2022).

1. Neuramis Deep: This was the first model certified by Thailand’s FDA. It doesn’t contain anesthetic and has a medium viscosity gel texture. It provides fullness and is easily moldable. Suitable for filling deep grooves on the face.

2. Neuramis Deep Lidocaine: Similar to the Deep model in texture, this version contains 0.3% lidocaine, an anesthetic, to reduce pain during injections.

The 2 models mentioned above have a decay time of approximately 6-8 months, depending on the lifestyle habits of each patient.

  • Neuramis Volume Lidocaine model has the most viscous gel texture among all models available. It is flexible and stable. Can be used to fill in moderate to severe wrinkle problems. and contains 0.3% anesthetic or lidocaine, which has the ability to blend well with the skin. flexible Can be shaped beautifully and the results of treatment can be maintained for approximately 12 – 24 months.

This is from all the information mentioned. Choosing the brand and quantity of filler that will be able to solve the problem with the most visible and clear results.

It depends on the diagnosis of the doctor who is sick, including the technique and experience of that doctor. Therefore, consulting with a doctor before receiving treatment is something that should not be overlooked.

  • 1 week before filler injection You should refrain from using pain relievers, aspirin, anti-inflammatory drugs such as Ibruprofen, Ponstan, Naproxen to prevent bruising after filler injections, including drugs or extracts that make it difficult for blood to stop, such as fish oil, garlic, vitamin E, ginseng leaf extract. Ginkgo, even collagen-supplemented food products
  • 3 days before filler injection You should refrain from using drugs that have the effect of exfoliating skin cells, such as Vitamin A substances such as Retin-A, Retinoid, or acid exfoliating acid groups AHA, BHA, and refrain from exfoliating the skin. Waxing or shaving the area where the filler was injected. To prevent inflammation and irritation, filler injections.
  • If you have a congenital disease and have medicine that you must take regularly. Information should be given to the doctor in question so that the treating doctor can diagnose and explain the side effects that may occur after the filler injection. For the highest safety of the patient as well and
  • If you have a history of allergic reaction to anesthetics You should inform the treating doctor as well because filler injections in some positions require anesthesia to be injected and in some brands of filler, anesthetic is mixed into the product.
  1. Consult a doctor Let the doctor of the patient evaluate the problem and tell you the points that need to be fixed.
  2. The doctor will recommend the appropriate filler brand and amount for the injection site. (Depends on the doctor’s diagnosis)
  3. Clean face If you have makeup on Makeup must be wiped off in the area where you want to inject it first.
  4. Before injecting filler The doctor will have to unpack the filler and view it in front of you. At this stage, the patient can check whether the filler is genuine or not.
  5. Apply ice to reduce pain from the needle.
  6. When the filler injection is finished The treating doctor will advise you on how to take care of yourself in various steps, including what you should do to get the best treatment results.

After getting filler injections, there might be some temporary symptoms like redness or swelling around the injection site. Redness usually fades in 2-3 days, and swelling is normal and heals naturally. Significant results become visible around 7-14 days after the swelling and redness go away.

  • Avoid touching, picking, scratching, and massaging the injection site. Because from opening the wound, it may result in the patient having swelling, redness, bruising, which is normal and will gradually improve within 2-3 days.
  • Apply disinfectant within 48 hours after injection to reduce swelling and inflammation of the skin.
  • Stay in a cool place. Avoid all types of heat and activities that cause redness of the face for at least 48 hours, such as saunas, heavy exercise, exposure to the sun, and all types of laser procedures that heat the deep layers of the skin for at least 1 month.
  • Try to move the skin at the injection site as little as possible. Especially during the first 2-3 days because it may cause the filler to move and lose its shape.
  • Avoid eating certain types of foods that can affect inflammation, swelling, and slow down the filling of the filler, such as drinking alcohol. Grilling Including fermented food and various spicy foods that cause redness in the face During the post-injection period approximately 48 hours.

Sometimes, patients who have had filler injections might experience issues like swelling, lumps, or dissatisfaction with the results. This can cause loss of confidence. Fortunately, these concerns can be corrected by a qualified doctor. Usually, Hyaluronic Acid (HA) fillers dissolve naturally, but the speed depends on the brand’s features and technology.

If you want the filler to dissolve quickly, enzymes like Hyaluronidase can be used. This enzyme specifically targets breaking down Hyaluronan (HA) without harming other parts. After using the dissolving agent, it’s best to wait 5-7 days before getting new filler injections. Consulting with a doctor is essential to ensure safe and effective results.

You don’t have to wait for it to break down, you can inject more. Multiple filler injections are not dangerous. If injected with a substance that can decompose itself, such as a filler type Hyaluronic Acid (Hyaluronic Acid: HA), it will be safe and can be refilled continuously without having to wait for it to break down first. Because of the nature of the filler, it can last for a maximum of approximately 18-24 months. It cannot be permanent. If the filler is completely dissolved The facial structure will return to its original state. Therefore, you can keep adding new ones to maintain your facial shape without worrying that it will be dangerous.

After the old filler has completely broken down You can change the brand of filler you use. There is no need to use the same brand of filler as in the past. However, you should receive advice from the doctor who has the patient that the patient’s problem is Which brand and model is suitable or should you choose? Because each filler has different properties and molecular sizes. Some are suitable for deep wrinkles. Some are suitable for small wrinkles.

After injecting the filler, you will see immediate results. The swelling will go away on its own in 7 – 14 days, and after about 2 weeks, after the swelling has subsided, the filler is in place and the results will begin to be more noticeable.

A filler, also known as hyaluronic acid filler, is a substance that helps keep our skin moisturized and firm. It imitates a natural substance in our body called hyaluronic acid, which holds water and maintains skin elasticity.


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